Three unlikely friends-Doris, a sassy eighty year old; Georgia, a mother recently divorced by her cradle-robbing ex-husband; and Abby, a senior in high school-meet during chemotherapy. When Doris is attacked by a thief and uses the skills she learned in self-defense to take him down, she proposes a preposterous idea during one of their monthly brunches: they should become superheroes. The other women laugh at first, but when their lives take turns they weren't expecting, they both agree to Doris's offer. The women take on local crime one fumbling rescue after another, as well as find romance, but just when The Troublemakers finally figure everything out, tragedy strikes. Will the group of women be able to conquer their enemies, both inside and out?