A brilliant Rhodes Scholar whose love life is torn in threes, Annabel Greeley is not lacking in wit or intellect. But when the accomplished geneticist is faced with a decision that will change not only her life, but the future of humanity, the answers elude her. She is hounded by the ever-present and unavoidable fact that she would not be alive if it weren't for her Aunt Lily, who happened to have Down syndrome and, seemingly, all of life's answers. Annabel's life is about to change in profound and paradoxical ways as she sets out in search of the things Lily knew.