The Sister Gospels depict the intertwining lives of four close-knit, African-American sisters as each embark on their own tumultuous path to growth and self-discovery. Greta Pierson James, the eldest at forty-three, is married to a white Southerner and lives with him and their ten-year-old son in Manhattan. She and husband Edwin are born-again Christians whose faith in God is rocked to the core after experiencing a harrowing, tragic loss. Venice Pierson is a successful television writer for a top-ten, Nielson ratings hit filmed on location in Chicago. She is single and married to her career but, consequently, falls in love with one of the show's wedded cast members who plays a character she helped create. Lorraine Pierson Crawford is a devoted, stay-at-home wife and car-pooling PTA mom living with her family in an upscale Long Island suburb. However, an unsuspecting, menacing force turns this church-going, suburban housewife's orderly world upside down. Naomi Pierson Eberhardt, the youngest, is the recently divorced, former wife of baseball superstar, Darryl Eberhardt. At twenty-nine, Naomi is trying to find her own way after living a life of luxury and privilege marred by deep emotional wounds inflicted by a philandering ex-husband. It is through life pathos such as these that thoroughly test the sisters' strength of character while generating personal growth as they draw closer to God and one another.