An encyclopedic collection of key scientists and the tools and concepts they developed that transformed our understanding of the physical world.

Many are familiar with the ideas of Copernicus, Descartes, and Galileo. But here the reader is also introduced to lesser known ideas and contributors to the Scientific Revolution, such as the mathematical Bernoulli Family and Andreas Vesalius, whose anatomical charts revolutionized the study of the human body. More marginal characters include the magician Robert Fludd. The encyclopedia also discusses subjects like Arabic science and the bizarre history of blood transfusions, and institutions like the Universities of Padua and Leiden, which were dominant forces in academic medicine and science.