Why is someone murdering all passengers and crew of Flight 2251 from two years ago? A mild-mannered underachiever is picked up by the FBI and informed that he is the last survivor of that flight -everyone else who was on board had already been eliminated - and that they would guarantee his safety if he helped with the investigation. But before the day is out an attempt is made on his life and his newly appointed FBI bodyguard is shot. The last survivor of the flight now finds himself alone and on the run for the first time in his life, evading someone he does not know who wants him dead for reasons he does not understand. Fearful of going to the authorities lest his pursuers find him again, his only hope now lies with Doc Minus Two, a rough, gruff failed doctor turned P.I. who lives on the outskirts of society and whom even his best friend describes as "the worst character you'll ever meet." Soon the two discover that the key to the bizarre murders can only be found in the Minotaur Labyrinth in Crete: a cave where old legends loom large and not everyone who goes in comes out alive.