In 2000, the Clay Foundation announced a historic competition: whoever could solve any of seven extraordinarily difficult mathematical problems, and have the solution acknowledged as correct by the experts, would receive 1 million in prize money. There was some precedent for doing this: In 1900 the mathematician David Hilbert proposed twenty-three problems that set much of the agenda for mathematics in the twentieth century. The Millennium Problems- chosen by a committee of the leading mathematicians in the world- are likely to acquire similar stature, and their solution (or lack of it) is likely to play a strong role in determining the course of mathematics in the twenty-first century. Keith Devlin, renowned expositor of mathematics and one of the authors of the Clay Institute's official description of the problems, here provides the definitive account for the mathematically interested reader.