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Targeting Trafficking in Drug Development

Targeting Trafficking in Drug Development


en Limba Engleză Paperback – 15 feb 2019
Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.
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Specificații

ISBN-13: 9783030089276
ISBN-10: 3030089274
Pagini: 425
Ilustrații: VIII, 425 p. 57 illus., 55 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.64 kg
Ediția:Softcover reprint of the original 1st ed. 2018
Editura: Springer Nature Switzerland AG
Locul publicării:Cham, Switzerland

Cuprins

1. Intracellular trafficking of gonadotropin receptors in health and disease.- 2. Investigating internalization and intracellular trafficking of GPCRs.- 3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors.- 4. Targeting of disordered proteins by small molecules in neurodegenerative diseases.- 5. Pharmacoperones for misfolded gonadotropin receptors.- 6. Pharmacological chaperones: Beyond conformational disorders.- 7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer.- 8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches.- 9. Conserved oligomeric Golgi and neuronal vesicular trafficking.- 10. SLC6 transporter folding diseases and pharmacochaperoning.- 11. The molecular physiopathogenesis of islet amyloidosis.- 12. Folding defects leading to primary hyperoxaluria.- 13. Potentialpharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria.    

Caracteristici

Broadens your understanding of therapeutic intervention at the level of trafficking Suitable for both experts needing information on recent advances and new researchers in the area Written by leading authorities in the field of protein trafficking