This book consists of advanced information regarding the immunopathology and clinical aspects of systemic sclerosis (SSc). Systemic sclerosis, often called as Scleroderma (tight skin) is a skin disorder characterized by excessive creation of collagen fibers in the skin, which further leads to fibrosis. Growing evidence reflects three pathological hallmarks which are implicated in SSc: activation of fibroblasts, endothelial dysfunction and autoantibody formation - whose correct order has not yet been concluded. This book contains updated information regarding the clinical features and pathogenesis of this serious syndrome. This book aids both researchers and clinicians in handling patients with this syndrome.