Systemic sclerosis or systemic scleroderma is an autoimmune disease of the connective tissue. The condition is characterized by the thickening of the skin due to a deposition of collagen and injuries to small arteries. Systemic sclerosis is of two types- localized and systemic. The localized condition affects the skin of the hands, feet and the face, while the systemic condition involves the heart, lungs, kidneys and gastrointestinal tract. Death due to sclerosis often occurs due to heart, lung and kidney involvement. Sclerosis is also considered to be a risk factor for cancer. The diagnosis of sclerosis is based on clinical examination, biopsy and presence of autoantibodies. There is no known cure for sclerosis. Treatment consists of NSAIDs, calcium channel blockers and topical therapies for improving pain and ulceration, and relieving other symptoms. This book elucidates the concepts and innovative models around the management of systemic sclerosis. It presents researches and studies performed by experts across the globe. Students, researchers, experts and all associated with immunology will benefit alike from this book.