Systemic lupus erythematosus is a chronic inflammatory disease, in which the immune system attacks healthy tissues of the body. It is one of several diseases that mimics other illnesses. Its diagnosis can thus be elusive. Some of the initial and chronic signs associated with this condition are malaise, fever, joint pains, fatigue, rashes and muscle pains. Around 70% of people with lupus have skin symptoms. Multiple genes have an influence in the development of lupus. It may also be triggered by drug reactions but is largely reversible. The severity of the disease in an individual needs to be assessed correctly to successfully treat lupus. The treatment involves the use of non-steroidal anti-inflammatory drugs and anti-malarial drugs. Certain forms of lupus nephritis require cytotoxic drugs such as mycophenolate and cyclophosphamide. This book aims to shed light on some of the unexplored aspects of systemic lupus erythematosus and the recent researches in this condition. The various studies that are constantly contributing towards advancing the diagnosis and management of lupus are examined in detail. Those in search of information to further their knowledge will be greatly assisted by this book.