Structure-Based Drug Design (NATO Science Series E:) de P.W. Codding

Structure-Based Drug Design: Experimental and Computational Approaches: NATO Science Series E:, cartea 352

P.W. Codding

Structure-Based Drug Design brings together scientists working on different aspects of the subject, demonstrating the necessary collaboration and interdisciplinary approach to this complex area. The focus is on X-ray crystallographic and computational approaches. The general aspects of these approaches are introduced in the first six articles. The remaining articles provide examples of the application of X-ray crystallography, molecular modelling, molecular dynamics, QSAR, database analysis, and homology modelling. The papers cover a wealth of interesting problems in the design of new and enhanced pharmaceuticals.

Citește tot Restrânge

	Preț	Express
Paperback (1)	908^.00 lei 43-57 zile
SPRINGER NETHERLANDS – 9 dec 2010	908^.00 lei 43-57 zile
Hardback (1)	913^.75 lei 43-57 zile
SPRINGER NETHERLANDS – 31 aug 1998	913^.75 lei 43-57 zile

Preț

Express

Paperback (1)

908^.00 lei 43-57 zile

SPRINGER NETHERLANDS – 9 dec 2010

908^.00 lei 43-57 zile

Hardback (1)

913^.75 lei 43-57 zile

SPRINGER NETHERLANDS – 31 aug 1998

913^.75 lei 43-57 zile

Din seria NATO Science Series E:

24%

Preț: 1712^.87 lei
15%

Preț: 566^.67 lei
15%

Preț: 572^.94 lei
15%

Preț: 571^.73 lei
15%

Preț: 578^.92 lei
15%

Preț: 580^.45 lei
15%

Preț: 568^.69 lei
15%

Preț: 578^.42 lei
15% $Measurement of Residual and Applied Stress Using Neutron Diffraction$

Preț: 583^.95 lei
Preț: 382^.65 lei
Preț: 372^.15 lei
20%

Preț: 333^.06 lei
Preț: 408^.17 lei
18%

Preț: 1176^.56 lei
18%

Preț: 1764^.96 lei
18%

Preț: 1181^.44 lei
Preț: 366^.56 lei
Preț: 393^.75 lei
18%

Preț: 1769^.50 lei
5%

Preț: 353^.34 lei
Preț: 391^.71 lei
18%

Preț: 1766^.62 lei
Preț: 404^.30 lei
Preț: 384^.13 lei
Preț: 383^.59 lei
18%

Preț: 2907^.74 lei
Preț: 374^.14 lei
5%

Preț: 376^.18 lei
18%

Preț: 1180^.81 lei
18%

Preț: 1181^.87 lei
18%

Preț: 1186^.41 lei
5%

Preț: 3393^.87 lei
18%

Preț: 1768^.29 lei
5%

Preț: 364^.41 lei
18%

Preț: 1180^.06 lei
Preț: 377^.84 lei
Preț: 380^.62 lei
18%

Preț: 2392^.01 lei
5%

Preț: 1373^.66 lei
Preț: 380^.99 lei

Cuprins

Steroid Hormone Structure, Receptor Binding and Activity: Empirical Drug Design.- The Cambridge Structural Database System: Conformational Analysis from Crystallographic Data.- SAR, Scope and Limitations of Molecular Design Approaches.- Computational Strategies for Modeling Receptor Flexibility in Studies of Receptor-Ligand Interactions.- Application of Machine Learning in Drug Design.- 3D Molecular Similarity Methods: In Search of a Pharmacophore.- Collagenase and Family: Targets for Drug Design.- Drugs Targeting Influenza Virus Neuraminidase.- From Cyclohexane to FK506 — Conformational Analysis by Molecular Dynamics.- The Use of Uncoded ?-Amino Acids Residues in Drug Design.- Use of the Cambridge Structural Database to Study Non-Covalent Interactions: Towards a Knowledge Base of Intermolecular Interactions.- Immunoconjugates as Anti-Cancer Agents.- Database Searching using Protein Crystal Structures and Molecular Docking Procedures.- Recent Developments in Applying Machine Learning to Drug Design.- Structure-Based Design of Novel Heparin-like Anticoagulants.- Structure, Mechanism of Action and Inhibition of Dehydrogenase Enzymes.- In Search of Hypoglycaemic Agents for the Treatment of Non-Insulin Dependent Diabetes Mellitus.- 3D Molecular Similarity Methods: Application to Modeling HIV-1 Reverse Transcriptase Inhibitor Binding.- Computational Approaches to Modeling Receptor Flexibility upon Ligand Binding: Application to Interfacially Activated Enzymes.- Exploring Drug Design Methods with Thymidylate Synthase.- Computational Tools for Structure-Based Drug Design.- Antibody-Antigen Interactions — Lessons in Molecular Design.- Antibacterial Design Based on the Structures of Gyrase-Inhibitor Complexes.- Integrated Homology Modelling and X-ray Study of Herpes SimplexVirus I Thymidine Kinase.