A brilliant endodontist has pioneered the stemwinder technique, a revolutionary medical procedure whereby the totipotent stem cells are extracted from the root canal. Dr Shine has made a fortune perfecting his prominent patients in New York. His staff cannot keep up with the philanthropist. Dr Shine bumps into Dr Gum at a colleague's funeral. He offers Dr Gum a position to join him at NYU and leave the implant dentistry behind. Dr Gum and his assistant Christie visit him and are fascinated with the incredible advances but are not convinced. Dr Shine urges Dr Gum to visit a sister clinic in Singapore, Stemtronics. Loosely based on Biopolis, the aspiring best research facility in the world where he meets Dr Lee. The budding scientist and prize pupil is being groomed by the Confucian master of the stem cell centre, Dr Sunwah. Back in New York, Dr Shine is dabbling in every imaginable altruistic and pleasurable pursuit including a film production. One of the aspiring actresses comes to the clinic for a referral, her curiosity piqued by the charismatic dentist. She discovers another side of the elusive endodontist. In Singapore, Dr Gum and Dr Lee uncover identity of a promising scientist. The recent acquisition is not who he appears to be. They delve deeper into the dilemma to discover a deep dark deadly secret of Stemtronics and must put a stop to it.