Sire is a family saga, about three siblings who are vampires. Hope Holly is a medical student and unwilling vampire that falls in love with a young man who is dying of cancer. Hope struggles to help him, while trying to reverse her vampire curse. Her siblings, Jonah and Helena are blood thirsty twins out to stop her by any means necessary, including death. Caught in this terrifying and tender triangle of temptation is not only the Holly family, but Nurse Stella Donahue, her brother, Mike Woods; a secret agent, and their sister, Nina Woods; a nun/wanted criminal. Two different factions race toward opposite end games ?one wants to save mankind and the other, wants to save their kind.