In 27.6 hours, Suzanne Sawyer will cease to exist. With little tolerance for error and a desire for immediate results, she relentlessly pushes her scientific research team forward with one goal in mind: miniaturizing organic matter. Though they resent her treatment of them, they know they're on the verge of a breakthrough. While preparing for their latest test, a computer malfunction traps Suzanne inside the reduction chamber. Her team tries to power down the system and unlock the door, but they are seconds too late. After a blinding flash of light, Suzanne is knocked unconscious. She wakes up in the familiar surroundings of the lab, angered by the team's failure which cost her a few inches of her height. As time passes, her desk chair rises higher and her clothes grow looser. The exposure is still taking effect, and calculations confirm that she's shrinking at an alarming rate of two and a half inches per hour. Her team must quickly develop a method to stop and reverse the process-and save Suzanne's life-before time runs out. As the lab and its occupants loom larger, she investigates the mishap only to discover that it wasn't an accident. Someone wanted her to disappear.