In a 2013 Healthcare Cost and Utilization Project Statistical Brief by the US Agency for Healthcare Research and Quality, septicemia was ranked as the number one most expensive national inpatient hospital cost. This ranking comes in spite of substantial advances in the clinical management of sepsis over the past fifteen years. While adherence with internationally established sepsis management protocols have demonstrated reduction in mortality and hospital/ICU length of stay, compliance with these protocols remains poor. This book discusses risk factors, management and prognosis of septic shock in individuals.