This volume addresses questions in the history of science and allied disciplines, about the inseparable relation between science and politics. Cases presented in the book shed light on the political conditions, orientation and the consequences of science. Together, they articulate frames of inquiry in historical-political epistemology. Situated in the early modern historical context, the volume draws attention to different political factors which shaped scientific practices and their ideologies. Given the contested historiographies of the scientific revolution, the critical approach of this volume offers an invitation for further historical inquiries on the practices and politics of science.