The book entitled "Schistosomiasis: Epidemiology, Diagnosis and Treatment", published by Nova Science Publishers Inc. presents a very interesting overview on this tropical parasitic disease in the post-genomic era. The book is a collection of 8 chapters written by world-renown health professionals and researchers, highly active in the field. The mainly targeted public is MDs specialising in Tropical Medicine as well as experienced Researchers and Professionals who are faced with the challenges of this ancient threat to human health. This book is conceptually divided into two sections: (1) a broad recollection of the up-to-date state of the comprehension of Schistosomiasis, including its interplay with the human host; (2) a focused survey on specific field studies, presenting the actual challenges of the disease. The first part, composed of 4 chapters, is preparatory to a better understanding of the case studies in the second part. Special attention has been put on three selected at risk categories of people: pre-school aged children, women, and travellers/migrants; the first two living in endemic areas, and the latter in non-endemic regions. In between these two sections is the chapter on zoonotic schistosomiasis, a neglected research area that shows the dangerous role of infected livestock in maintaining the disease in endemic countries.