The world all but ended less than one month after the Lyssa-Niuhi virus ravaged its first human host. Now, those still living face an unending struggle for survival in a lawless land overrun by infected revenants hell-bent on their demise. Unwilling to accept probable extinction without a fight, John Wild decides to take a stand against the plague that destroyed his family, as well as nearly all of humanity. Spurred on by the prospect of finding a cure, and accompanied by a small band of like-minded survivors, they fight tooth and nail against man and rev alike as they travel to meet John's longtime friend, neurobiologist Dr. Lin San. Even as they prepare to leave, John clings to the hope that his daughter, Ava, is still alive. That notion, along with the help of those who fight by his side, is the only reason John has not succumbed to the apocalyptic wasteland. This is their journey-the beginning of their riposte.