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Resveratrol: Sources, Production & Health Benefits de Dominique Delmas

Resveratrol: Sources, Production & Health Benefits

Editat de Dominique Delmas
en Limba Engleză Hardback – apr 2013

Lucrarea Resveratrol, coordonată de Dominique Delmas, aduce o perspectivă integrată și exhaustivă asupra unuia dintre cei mai studiați compuși de origine vegetală, trans-3,4',5-trihidroxistilbenul. Față de literatura existentă, acest volum se distinge prin acoperirea întregului ciclu de viață al polifenolului: de la procesele de inginerie în bioreactoare comerciale până la cele mai recente studii clinice și dezvoltarea de derivați farmacologici. Subliniem faptul că textul nu se limitează la beneficiile nutriționale, ci explorează mecanismele celulare complexe, cum ar fi căile enzimatice și expresia genică, oferind o bază științifică solidă pentru cele peste 4.500 de studii indexate anterior.

Structura este riguros organizată în zece secțiuni. Primele părți sunt dedicate surselor naturale și metodelor avansate de analiză, precum UHPLC-PDA și tehnicile voltametrice. Progresia narativă continuă cu impactul fiziopatologic, detaliind proprietățile antioxidante, cardioprotectoare și antiinflamatorii. Merită menționat că volumul alocă spațiu considerabil unor domenii emergente, precum rolul microRNA și neuroprotecția în afecțiuni ca Alzheimer sau Parkinson. Ca alternativă la Bioactive Polyphenols from Wine Grapes de Jeffrey A. Stuart pentru cursurile de biochimie, lucrarea de față are avantajul unei abordări mult mai vaste, care include farmacocinetica detaliată și aplicațiile în industria cosmetică sau a suplimentelor alimentare.

Credem că rigoarea cu care sunt tratate procesele de biodisponibilitate și metabolismul compusului face din acest titlu o resursă superioară manualelor care se concentrează doar pe epidemiologie. Este o sinteză tehnică ce transformă datele brute de laborator în perspective aplicabile pentru medicina preventivă și tratamentul bolilor degenerative contemporane.

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Specificații

ISBN-13: 9781620819975
ISBN-10: 162081997X
Pagini: 587
Ilustrații: illustrations
Dimensiuni: 180 x 255 x 46 mm
Greutate: 1.21 kg
Editura: Nova Science Publishers Inc
Colecția Nova Science Publishers, Inc (US)
Locul publicării:United States

De ce să citești această carte

Recomandăm această lucrare studenților la medicină și farmacie, precum și cercetătorilor din biochimie. Cititorul câștigă o înțelegere profundă a mecanismelor moleculare prin care resveratrolul influențează sănătatea umană, beneficiind de o analiză critică a celor mai noi studii clinice. Este un instrument esențial pentru a separa datele factuale de promisiunile comerciale din industria suplimentelor.

Descriere

A wide variety of plant-derived compounds, including polyphenols, are present in the human diet and may protect against vascular diseases, cancers, viral infections, neurodegenerative processes and associated anti-inflammatory effects. Among these bioactive compounds, several A wide variety of plant-derived compounds, including polyphenols, are present in the human studies revealed that resveratrol, a trans-3,4',5-trihydroxystilbene, found in various natural products may be one of the main wine micro-components responsible for health benefits. Indeed, this polyphenol possesses a myriad of beneficial effects and can act at multiple levels, such as cellular signalling, enzymatic pathways and gene expression. Many laboratories have studied the molecular and cellular mechanisms of resveratrol in various models to get insight into its mechanisms of action in various disease processes. The increase of resveratrol interest is both reflected by the number of publications in databases, approximately 4,520 in Medline, and by the large number of patents copyrighted by biotechnology companies with new applications in cosmetic fields, central nervous system, food complement, preparations, to better understand the origins of resveratrol, its cellular and molecular mechanisms in plants and humans, this book on resveratrol has been divided into sections ranging from natural and industrial production to the latest scientific advances and clinical trials through the participation of leading scientists in each area covered in this book. Section 1 describes the sources and new engineering processes for custom and commercial bioreactors production of resveratrol. Section 2 is devoted to the common and new methods of resveratrol analysis. The following sections concern the health benefits of resveratrol. Section 3 shows the anti-oxidant properties of resveratrol in various physiopathological states. Section 4 focuses on the cardioprotective effects of resveratrol and the improvement of the endothelial function. Section 5 deals with metabolic disorders and the potential use of resveratrol in the prevention and treatment of obesity and osteoporosis. Section 6 is dedicated to health benefits of resveratrol against inflammation and associated diseases such as rheumatoid arthritis. The role of new targets such as microRNAs in the biological response of resveratrol is also discussed. Section 7 describes the anticancer properties of resveratrol through the chemoprevention of various cancers, the modulation of cell cycle, the induction of apoptosis and DNA damages. Section 8 reviews the potential use of resveratrol in neuroprotection such as neurovascular system and neuroglial plasticity, and in the prevention and treatment of neurodegenerative diseases such Alzheimer's and Parkinson's diseases. Besides the prevention of a number of diseases, other aspects such as dietary intake and bioavailability are important for the comprehension of resveratrol mechanisms of action. In this area, section 9 provides an overview of the metabolism of resveratrol, its pharmacokinetics and the recent advances in resveratrol delivery. The last part of this book, section 10, is dedicated to the clinical development of resveratrol and to the future development of resveratrol derivatives to provide new pharmacological tools for treatment of various diseases. We hope that this book may provide a valuable tool for graduate and PhD students in sciences, biology, medicine and pharmacology and for scientist or clinicians working in this field or all the people using this polyphenol.

Cuprins

Preface; Resveratrol from Vine to Wine; Production of Grapevine Cell Biomass (Vitis vinifera L. Gamay) & Resveratrol in Custom & Commercial Bioreactors using Cyclodextrins & Methyl-Jasmonate Elicitors; Development of Voltammetric Techniques & Sensors for the Determination of Resveratrol; Adsorption Properties of Synthetic Determinations of Resveratrol; A Fast & High-throughput MEPS/UHPLC-PDA-based Methodology for Separation & Identification of Resveratrol in Wine; Antioxidant Properties of Resveratrol & Health Protection in Pathophysiological States; Resveratrol & Oxidative Stress of Ageing; Antioxidant Properties of Resveratrol & its Promising Effects in Cardiovascular Disease; Molecular Mechanisms on How Resveratrol Enhances Endothelial NO Production; Basis for Resveratrols Potential for Prevention & Treatment of Obesity & Osteoporosis; Resveratrol & Energy Metabolism; Resveratrol, a Potent Agent against Inflammatory & Oxidative Stress-Related Diseases; Evidence to Support Testing of Resveratrol for Efficacy in Rheumatoid Arthritis; Effects of microRNAs in the Biological Response of Resveratrol; Can We Prevent Cancer? The Role of Resveratrol in Chemoprevention; Therapeutic Potential of Resveratrol against Cancers: Focus on Cell Proliferation & Cell Death Pathways; Role of DNA Damage in the Antitumoral Activity of Resveratrol; Resveratrol & Neuroprotection; Resveratrol & Neurodegenerative Diseases; Sources & Food Matrix on the Bioavailability of Resveratrol; Pharmacological Activities, Pharmacokinetics & Delivery Approaches; Resveratrol & Cyclodextrins: Recent Advances in Encapsulation; Clinical Development of Resveratrol; Resveratrol Derivatives & Health Benefits; Index.