As young people, we all question the reason for our existence. When a young nurse named Amanda is present at the birth of James (Jamie) Harrington Jane and she gets to hold the baby, she feels a connection like she has never felt to anyone before. Growing up, Jamie seems destined to have an Amanda in his life, but it does not always bring him happiness. Through his liaisons with various Amandas, he experiences love, joy, and also loss. Amanda's repeated attraction to Jamie takes her on a treacherous road toward her ultimate destiny.