Radiation Biology: Molecular Foundations and Clinical Applications
Autor Barry S. Rosenstein, Jerome M. Karpen Limba Engleză Paperback – 20 oct 2026
In addition to its focus on molecular responses, the book covers topics like tumor microenvironment and metabolism, the role of epigenetics in radiation biology, and the hallmarks of cancer relevant to radiation therapy. It also provides discussions on chemotherapeutic agents, radiation carcinogenesis, and the complex interplay between radiation and cancer biology. The later sections extend the scope to tissue, organ, and systemic effects of radiation, making it an invaluable reference for professionals in molecular biology, oncology, and related fields striving to push the boundaries of radiation research.
- Focuses on the topic of radiation biology at the cellular and molecular level
- Addresses the topic from fundamentals through to clinical application
- Considers the latest advances in the field of radiation biology and radiation oncology
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Specificații
ISBN-10: 0443134685
Pagini: 450
Dimensiuni: 191 x 235 mm
Greutate: 0.45 kg
Editura: ELSEVIER SCIENCE
Cuprins
2. Radiation-Induced DNA Damages and DNA Repair Processes
3. Molecular Pathways of Cell Death
4. Radiotherapy and Immune Checkpoint Blockade
5. Molecular Signaling in Irradiated Cells
6. Cell-Survival Curves
7. Impact of Cell Cycle Phase, Dose Rate and Kinetic Factors on Radiation Responses
8. The Role of Oxygen in Irradiated Cells
9. The Use of Hypofractionation, Hyperfractionation and Accelerated Treatment in Radiotherapy
10. Angiogenesis, Microenvironment and Metastasis and Radiation Responses
11. Linear Energy Transfer and Relative Biological Effectiveness
12. Radiation Sensitizers
13. Radioprotectors and Radiomitigators
14. Particle Beam Radiotherapy
15. Predictive Assays in Radiotherapy
16. Interaction of Heat and Radiation
17. Classical and Targeted Chemotherapeutic Agents and Interaction with Radiation
18. Radiation Carcinogenesis
19. Hereditary Effects of Radiation
20. In Utero Radiation Effects
21. Radiation Protection Guidelines
22. Normal Tissue and Organ Radiation Responses
23. Whole-Body Radiation Effects
24. Topics in Cancer Biology Relevant to Radiation Oncology
Notă biografică
Dr. Rosenstein is a Professor of Radiation Oncology and a Professor of Genetics & Genomic Sciences at the Icahn School of Medicine at Mount Sinai. He is a renowned educator who has received numerous teaching awards. More than 600 trainees from multiple radiation oncology and medical physics residency programs have taken Dr. Rosenstein's 60-hour course in radiation and cancer biology. He also provides lectures in radiation biology and radiation safety for radiology residents. Dr. Rosenstein has served as a member of the Radiation Oncology Radiation/Cancer Biology Committee and the Radiology Physics Committee of the American Board of Radiology. He created and was the editor-in-chief of the widely used American Society for Radiation Oncology (ASTRO) Radiation and Cancer Biology Practice Examination and Study Guide. The focus of Dr. Rosenstein's research program has been the identification of genetic/genomic markers associated with the development of adverse effects resulting from radiotherapy.