Quantification, Validation and Uncertainty in Analytical Sciences

Table of Contents Preface 1. Quantification 1.1 Define the Measurand (Analyte) 2. Calibration 2.1 Direct and Inverse Calibration 3. Precision 3.1 Outputs of Interlaboratory Studies 4. Trueness 4.1 Trueness and True Value 5. Method Validation 5.1 Review of Validation Procedures 6. Measurement Uncertainty (MU) 6.1 Principle of Measurement Uncertainty 7. Measurement Uncertainty in Analytical Sciences 7.1 Published Procedures: an evaluation 8. Measurement Uncertainty and Decision 8.1 Framework for decision-making 9. MU and Quantification Limits 9.1 Definitions and Assessment of LOQ 10. Examples of MU Application 10.1 Standard Addition Method and Drug Quality 11. Conclusions 11.1 Role of the Number of Replicates 12. Annexes 12.1 The 10-step MAP procedure