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Protein Engineering for Therapeutics, Part A de K. Dane Wittrup

Protein Engineering for Therapeutics, Part A: Methods in Enzymology, cartea 502

K. Dane Wittrup, Gregory L. Verdine
en Limba Engleză Hardback – 23 feb 2012
This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Antibodies, Protein conjugates, Peptides, Enzymes and Scaffolds


  • Chapters provide an invaluable resource for academics, researchers and students alike
  • Iinternational board of authors
  • This volume is split into sections that cover subjects such as Antibodies, Protein conjugates, Peptides, Enzymes and Scaffolds
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Specificații

ISBN-13: 9780124160392
ISBN-10: 0124160395
Pagini: 392
Dimensiuni: 152 x 229 mm
Editura: ELSEVIER SCIENCE
Seria Methods in Enzymology

Public țintă

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Cuprins

  1. Simplified Synthetic Antibody Libraries
  2. Generation of Dual Variable Domain Immunoglobulin Molecules for Dual-specific Targeting
  3. Discovery of internalizing antibodies to tumor antigens from phage libraries
  4. Optimizing properties of anti-receptor antibodies using kinetic computational models and experiments
  5. Cell-specific siRNA delivery by peptides and antibodies
  6. Conjugation of Anticancer Drugs Through Endogenous Monoclonal Antibody Cysteine Residues
  7. Building and characterizing antibody-targeted lipidic nanotherapeutics
  8. Cell-Targeting Fusion Constructs Containing Recombinant Gelonin
  9. Stapled Peptides for Intracellular Drug Targets
  10. Mapping of vascular zip codes by phage display
  11. Engineering cyclic peptide toxins
  12. Peptide Discovery using Bacterial Display and Flow Cytometry
  13. Oral enzyme therapy for celiac sprue
  14. Rational Design and Evaluation of Mammalian Ribonuclease Cytotoxins
  15. Engineering Reduced-Immunogenicity Enzymes for Amino Acid Depletion Therapy in Cancer
  16. Designed Ankyrin Repeat Proteins (DARPins): From research to therapy
  17. Target-binding proteins based on the tenth human fibronectin type III domain (10Fn3)
  18. Anticalins: small engineered binding proteins based on the lipocalin scaffold
  19. T Cell Receptor Engineering
  20. Engineering Knottins as Novel Binding Agents
  21. Re-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier
  22. Practical Theoretic Guidance for the Design of Tumor Targeting Agents
  23. Fusions of elastin-like polypeptides to pharmaceutical proteins
  24. Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells