The large-scale study of proteins is known as proteomics. A set of proteins that is produced and modified by an organism or system is named as proteome. Proteomics has led to the identification of a large number of proteins. It is involved in the discovery of proteomes from various levels of protein composition, structure and activities. Proteomics plays an important role in functional genomics as well. Some of the common methods used in this field are protein detection with antibodies and antibody-free protein detection. It is applied in numerous fields such as identifying potential drugs and for revealing complex plant-insect interactions. This textbook presents the complex subject of proteomics in the most comprehensible and easy to understand language. Some of the diverse topics covered herein address the varied branches that fall under this category. Through this book, we attempt to further enlighten the readers about the new concepts in this field.