Nature always stands as golden mark to amplify the outstanding phenomenon of symbiosis. Medicinal plants existing even before human being made their appearance on the earth.The development procedure of herbal drugs for world-wide use has to been different form that of synthetic drugs. The raw materials for Ayurvedic medicines were mostly obtained from plant sources in the form of crude drugs such as dried herbal powders or their extracts or mixture of products or mixture of product. Apart from these systems there has been a rich heritage of ethno botanical usage of herbs by various colorful tribal communities in the country. A scrutiny of folk claims found 203 plants for evaluation. Less well known ethno medicines have been identified that are used to treat intestinal, joint, liver and skin diseases. Routine random efforts are not likely to increase the desired success rate of discovery, while experience indicated that a modified collection policy offers the best chances for the discovery and development of agents for the treatment of AIDS (acquired immune deficiency syndrome) and cancer.