Palliative care is an approach that improves the quality of life of patients and their loved ones when faced with problems inherent to a life-threatening illness. Physical exercise can improve or maintain physical and psychological well-being in palliative cancer patients. In order to optimize and contribute to the quality of life of patients with chronic and progressive diseases, this text explores the implementation of physical exercise in people with advanced cancer in a home setting, providing a particular view through a clinical case together with guidelines of our own elaboration.