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Perinatal Neuropathology de Mirna Lechpammer

Perinatal Neuropathology

Autor Mirna Lechpammer, Marc Del Bigio, Rebecca Folkerth
en Limba Engleză Paperback – 16 sep 2021
There is an increasing demand for high-standard fetal and infant neuropathology examinations. Novel imaging techniques, development of new diagnostic methods and advances in genetics have stimulated the interest in gaining additional knowledge on developmental, perinatal and neonatal neuropathology. Approaching the subject from a practical standpoint, diagnostic templates for reports are provided in this essential guide to aid clinicians with different areas of expertise. Each chapter will includes numerous high-quality images, accompanied by explanatory legends from the authors' own experiences. Covering autopsy and tissue processing techniques, the authors discuss a range of disorders such as neural tube defects, brain tumours, storage disorders and many others. This book provides access to an online version on Cambridge Core, which can be accessed via the code printed on the inside of the cover. Compiling the latest advances in fetal and infant diagnostics and care, this book is a highly valuable educational resource.
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Specificații

ISBN-13: 9781107159792
ISBN-10: 1107159792
Pagini: 458
Dimensiuni: 222 x 277 x 25 mm
Greutate: 1.85 kg
Editura: Cambridge University Press
Locul publicării:New York, United States

Cuprins

Part I. Techniques and Practical Considerations: Approach to autopsy of perinatal nervous system: 1. Clinical considerations; 2. Imaging; 3. External exam of fetus/infant; 4. Autopsy and research consent; Ancillary studies: 5. Microbiology; 6. Cytogenetics; 7. Metabolic studies; 8. Toxicology; Prosection techniques: 9. Brain; 10. Spinal cord; 11. Neuromuscular specimens; 12. Eye specimens; Tissue selection: 13. Selection of brain sreas for microscopic examination; 14. Technical considerations in perinatal CNS tissue processing; 15. Staining techniques; Reporting: 16. Formulation of diagnosis; 17. Reporting templates; 18. Medicolegal Considerations; Part II. Human Nervous System Development: Neuroanatomic Site Development: 19. Human nervous system development – embryonic and early fetal events; 20. Cerebral cortex, including germinal matrix; 21. White matter, including myelination; 22. Cerebellum development of rhombic Lip, cerebellar cortex, dentate nucleus; 23. Spinal cord; 24. Skeletal muscle and peripheral nerve; 25. Fetal and infant eye; Growth parameters: Head size and brain weight; Part III. Stillbirth: Autolysis and Artifacts: 27. Autolysis and artefacts; Stillbirths: 28. Stillbirth; Part IV. Disruptions/Hypoxic-Ischemic Injury: Cellular Responses: 29. Neuronal death; 30. Macroglial reactions; 31. Inflammatory responses; Gray matter: 32. Supratentorial grey matter damage and disruptions; 33. Brainstem and spinal cord disruptions; white matter: 34. Periventricular leukomalacia and diffuse white matter injury; Germinal matrix: 35. Periventricular and intraventricular brain hemorrhage ; Cerebellum: 37. Cerebellar lesions; Part V. Malformations: Neural Tube Defects and Patterning Defects: 37. Defects of neural tube Closure and axial mesodermal defects; 38. Disorders of early midline patterning; Hydrocephalus: Fetal and perinatal hydrocephalus; Neuronal migration disorders: 40. Cerebral cortical migration disorders; Genetic syndromes and phacomatoses: 41. Fragile X syndrome; 42. Down syndrome; 43. Edwards's syndrome; 44. Patau syndrome; 45. Tuberous sclerosis complex; 46. Sturge-weber syndrome; 47. Neurocutaneous melanosis; Part VI. Congenital and Perinatal Brain Tumors: 48. Congenital and perinatal brain Tumors; Part VII. Spinal and Neuromuscular Disorders; Arthrogryposis: 49. Arthrogryposis; Spinal muscle atrophy (SMN AND NON-5Q SMA): 50. SMN and non-5q sMA,; Early-Onset hereditary neuropathies: 51. CMT neuropathies; Congenital muscle disorders: 52. Congenital myasthenic syndromes; 53. Congenital muscular dystrophies; 54. Congenital myopathies; 55. Other congenital muscle diseases; Part VIII. Eye Disorders: Congenital Eye Disorders: 56. Congenital eye malformations and Deformations; Part IX. Infections in Utero Infections: Congenital viral, bacterial, and parasitic infections; Peri- and postnatal infections: 58. Meningitis and encephalitis; Part X. Metabolic/Toxic Disorders: Storage diseases: Lysosomal Disorders; 60. Peroxisomal Disorders; Kernicterus: 61. Kernicterus; Mitochondrial diseases: 62.Mitochondrial diseases; Maternal toxin exposure: 63. Ethanol and other agents; Part XI. Forensic Neuropathology: Trauma: 64. Birth trauma; 65. Accidental and non-accidental death; Sudden unexpected death in infancy and childhood: 66. Sudden unexpected death in infancy and childhood.

Descriere

Provides comprehensive and contemporary guidance on the optimal approach to fetal and infant neuropathology.