This book is a leverage in understanding patch clamp technique. This book is a compilation of researches related to patch clamp technique accomplished by experts around the globe. It is basically an electrophysiological method for calculating the electric current created by a living cell. This innovative method was discovered by two professionals of Germany - Erwin Neher and Bert Sakmann. They were honored with the prestigious Nobel Prize in 1991 for their contribution to Medicine. It is even used for calculating the drug result against a sequence of diseases, and to find out the mechanism of disorders in animals and plants. It is also applied in getting the structure function actions of compounds and drugs; and major pharmaceutical firms use this method in clinical trials of their medicines. In simple words, this book deals with the theory of endogenous mechanisms of cells and its practical functions. It presents the fundamental principles and developing varieties, as well as deals with the most recent advancements in the established patch clamp method. This book intends to help students and experts in gaining more knowledge regarding this innovative technique.