When agoraphobic Gabe and his outgoing nemesis Jessa go on a moonlit road trip to locate Gabe's missing brother, the two teens discover they are both hiding unnatural abilities: Gabe is a living lie detector and Jessa is a kick-ass powerhouse pretending to be a delicate diva. Gabe's sole reason for searching for Watts, his hot-tempered younger brother, is to clear his own name: he's been framed for Watts' alleged murder. Jessa is after Watts because she is, well, "after" him. They find him with Deacon, the twisted eugenicist responsible for their unusual powers. He encourages them to stay and join his "Family" where they'll be able to live openly as the genetically-modified freaks that they are. When Jessa and Gabe uncover the truth about Deacon's past--and what he wants for the future--they band together to stop him. Watts, however, may have other plans . . .