When a goose crashes onto their roof, the lives of Oswald, a fame-seeking opossum, and his best human friend, shy, ten-year-old Joey, are turned upside down. Oswald's persistent attempts at fame alienate all his friends, human and animal, so he tries to atone with a big party. But plans go awry when another animal falls into a pot of vegetarian chili, and Joey's mother, Ann, is mistakenly arrested for animal cruelty. For once, Oswald thinks of someone other than himself. He enlists three raucous raccoons and a sarcastic cat to make a video to prove Ann's innocence. With Joey's help, it goes viral. All charges against Ann are dropped, Joey finds his feet with new friends, and Oswald gets an offer from Hollywood. But will fame make the opossum happy, after all?