Osteosarcoma is a malignant tumor of bone in which there is a proliferation of osteoblasts. This book has been compiled to keep the readers acquainted with latest research on osteosarcoma, a feared primary bone cancer. The pace of developments in managing osteosarcoma has declined after the growth of chemotherapy and limb saving surgical procedure. Studies have now been headed towards identifying molecular targets for systemic treatment. Accessibility of chemotherapy medicines and low cost implants in the developing world has led to limb saving surgical procedure to advance. This book overviews the present fundamental information on osteosarcoma and elaborates some of the improvements which have the potential to modify the prognosis.