The Orb-Univerous have been very innovative, each time mankind tries to make a hold the creatures come up with something new, something more deadly, they bring in alien creatures to do their dirty work and then they do something that will change everything. The crew on the Streamer forges new friends and allies; they team up to save anyone they can before everyone becomes a host, and they lose good friends along the way while some switch sides. But it's up to Bo to break them or make them even more invincible.