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Occupational Asthma de Torben Sigsgaard

Occupational Asthma: Progress in Inflammation Research

Editat de Torben Sigsgaard, Dick Heederik
en Limba Engleză Hardback – 15 apr 2010

Ne-a atras atenția această lucrare de referință care își extrage rigoarea din studii clinice recente și meta-analize din sfera medicinei muncii, oferind o perspectivă clinică asupra astmului ocupațional. Publicată în seria Progress in Inflammation Research sub egida editurii birkhäuser, Occupational Asthma investighează contribuția expunerilor profesionale la agenți chimici și biologici, propunând o abordare fundamentată pe dovezi pentru diagnosticul și managementul acestei patologii.

Descoperim aici o structură riguroasă, care debutează cu evoluția istorică și epidemiologia riscurilor respiratorii, avansând spre mecanismele moleculare ale sensibilizării. Un element distinctiv al volumului coordonat de Torben Sigsgaard și Dick Heederik este utilizarea studiilor pe ucenici — populații tinere, fără expunere anterioară — care permit observarea apariției simptomatologiei în timp real. Cartea nu se rezumă la teorie; ea introduce reguli de diagnostic precise pentru a diferenția astmul cauzat de locul de muncă de cel agravat de mediul profesional, optimizând astfel schemele de supraveghere medicală.

În contextul literaturii de specialitate, Occupational Asthma completează titlul Asthma in the Workplace de Susan M. Tarlo prin accentul pus pe genetica populațională și interacțiunile genă-mediu, oferind instrumente metodologice pentru proiectarea studiilor epidemiologice proprii. Dacă lucrarea lui Tarlo utilizează scenarii de caz pentru practică, volumul de față aprofundează screening-ul genomic și relațiile expunere-răspuns pentru alergeni, fiind esențial pentru cercetătorii care doresc să înțeleagă patofiziologia inflamației căilor respiratorii în medii industriale și agricole.

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Specificații

ISBN-13: 9783764385552
ISBN-10: 3764385553
Pagini: 376
Ilustrații: XIII, 358 p.
Dimensiuni: 170 x 241 x 26 mm
Greutate: 0.78 kg
Ediția:2010
Editura: birkhäuser
Colecția Progress in Inflammation Research
Seria Progress in Inflammation Research

Locul publicării:Basel, Switzerland

Public țintă

Research

De ce să citești această carte

Această lucrare este indispensabilă medicilor de medicina muncii și pneumologilor care doresc să implementeze protocoale de supraveghere bazate pe dovezi. Cititorul câștigă acces la metodologii avansate de cercetare și criterii de diagnostic care îmbunătățesc raportul cost-beneficiu în clinică. Este un instrument critic pentru înțelegerea modului în care genetica individuală influențează susceptibilitatea la astm în fața poluanților industriali.

Cuprins

The history of research on asthma in the workplace — Development, victories and perspectives.- Epidemiology and risk factors of occupational respiratory asthma and occupational sensitization.- Epidemiology of laboratory animal allergy.- Population-attributable fraction for occupation and asthma.- Definition and diagnosis of occupational asthma.- Work-exacerbated asthma.- Natural history and prognosis.- Mechanisms of allergic occupational asthma.- Mechanisms of occupational asthma caused by low-molecular-weight chemicals.- Asthma-like diseases in agriculture.- Allergen and irritant exposure and exposure-response relationships.- Gene-environment interactions in occupational asthma.- Asthma in apprentice workers The birth cohort parallel: Using apprentices as a powerful cohort design for studying occupational asthma.- Management of an individual worker with occupational asthma.- Social consequences and quality of life in work-related asthma.- Prevention of work-related asthma seen from the workplace and the public health perspective.- Prevention and regulatory aspects of exposure to asthmagens in the workplace.- Design, conduct and analysis of surveys on work-related asthma.

Recenzii

From the reviews:
“The editors of this book weave together developments in the field of occupational asthma research and clinical practice and further investigate the contribution of occupational exposures to both chemical and biological agents. … Reasonably speaking, the reach of this book goes … cohort of occupational asthma researchers to a much wider range of clinicians, basic scientists, and toxicologists. … this book is important in increasing knowledge and effectiveness among clinicians and related engineering personnel who must prevent occupational asthma from occurring.” (J. Thomas Pierce, Doody’s Review Service, April, 2011)

Textul de pe ultima copertă

Recent developments in the field of occupational asthma research and clinical practice are the topic of this volume. The contribution of occupational exposures to chemical and biological agents to the burden of asthma in adults is clearly described in an overview of the most recent epidemiological data from both general population and industry based studies. Emphasis is put on powerful approaches like the use of apprentices studies, which include young individuals, naïve with regard to occupational exposures. Diagnostic criteria for work related and work aggravated asthma are introduced and the latest insights in underlying mechanisms are covered as well. Specific emphasis is given to exposure response relationships for allergen exposure, which opens opportunities for primary and secondary prevention. Large gene-environment studies are undertaken for asthma and their contribution to understanding occupational asthma is discussed. Specific attention is given to whole genome screening approaches which involve with present technological possibilities the analysis of thousands of single nucleotide polymorphisms, versus the more focused candidate gene approach where genes with potential mechanistic plausibility are considered. Although the latter approach has been used more extensively, whole genome screening studies are becoming available soon, also for studies on occupational asthma. Management, prevention and surveillance are covered as well. All three areas are undergoing some changes in perception because of the exposure response relationships unraveled during the last decade. Diagnostic rules are introduced to rationalize the diagnostic workup and improve the cost benefit of surveillance schemes, and in preventive measures at large. This approach is only recently introduced in the field of occupational asthma and is expected to contribute even more in the coming years. Population studies, either general population studies, or work force based studies, havecontributed enormously to our understanding of disease etiology and in the costs related to the disease. Issues in the design of such studies are discussed to assist the readers in designing and conducting their own study. Altogether this book gives a comprehensive insight in the present developments which will change the occupational asthma field the coming years.

Caracteristici

Comprehensive volume with state-of-the-art reviews on OA International authorship