A maniac is murdering gang leaders in the desert outside San Diego, black magic is whispered in back alleys, and zombie tweekers roam the streets. The world stands on the brink of something sinister and occult but the only guy Donnie DeGrassi knows that can solve this supernatural puzzle is a recluse that hides out in his beach shack, talking to spirits and brewing hallucinogenic compounds. Some say he's crazy, others claim he's genius, but those that dose Kal Renley's chemicals just know him as the Medicine Man. Can Donnie get his old friend out of retirement before reality gets as ugly as the underworld?