Nuclear receptors are involved in various aspects of intracellular signal transduction within a range of tissues and play an important role as regulators in numerous essential biological functions. In this book, the authors present topical research in the study of nuclear receptors, including glucocorticoid receptor signalling in cardiovascular disease; steroid receptor coactivators and endocrine treatment in breast cancer; the effects of nitric oxide on nuclear receptors as a tool for studying gene regulation; vitamin K as a ligand of steroid and xenobiotic receptors and androgen receptors and prostate cancer.