To achieve energy security and greenhouse gas (GHG) emission reduction objectives, the United States must develop clean, affordable, domestic energy sources as quickly as possible. Nuclear power will continue to be a key component of a portfolio of technologies that meets our energy goals. This book provides a roadmap for the Department of Energy's (DOE's) Office of Nuclear Energy (NE) research, development and demonstration activities that will ensure nuclear energy remains a viable energy option for the United States.