Nonmalignant Hematology
Editat de Syed A. Abutalib, Jean M. Connors, Margaret V. Ragnien Limba Engleză Paperback – 27 iun 2018
Observăm că Nonmalignant Hematology se poziționează ca un instrument de lucru esențial, fiind un manual de referință comparabil cu Hematology in Clinical Practice, Fifth Edition, dar axat exclusiv pe patologia benignă și actualizat pentru a răspunde provocărilor clinice contemporane. Ne-a atras atenția abordarea pragmatică prin formatul de întrebări și răspunsuri, care transformă volumul dintr-o simplă resursă teoretică într-un ghid de decizie clinică rapidă, similar în spirit cu Non-Neoplastic Hematologic Disorders, însă cu o profunzime analitică superioară datorată celor peste 60 de capitole semnate de autorități recunoscute.
Descoperim aici o structură riguroasă ce pornește de la evaluarea anemiilor și fiziopatologia homeostaziei fierului, avansând spre tulburările complexe de coagulare și managementul bolilor tromboembolice. Un punct forte al lucrării este secțiunea dedicată hemostazei și trombozei în contexte fiziologice specifice, precum sarcina, perioada neonatală sau la pacienții vârstnici, oferind o perspectivă integrată pe care puține tratate o reușesc. Syed A. Abutalib își continuă aici misiunea de a clarifica aspecte clinice dificile, păstrând rigoarea demonstrată în lucrări precum Best Practices of Apheresis in Hematopoietic Cell Transplantation sau Cell and Gene Therapies, dar pivotând de această dată spre hematologia generală și oncologia pediatrică și de adulți.
Tonul clinic și precis al textului este susținut de opinii argumentate asupra unor subiecte controversate, oferind rezidenților și specialiștilor nu doar date, ci și raționamente medicale solide. Ediția publicată de Springer reușește să acopere veriga lipsă dintre cercetarea fundamentală și patul bolnavului, transformând complexitatea mecanismelor moleculare în soluții terapeutice aplicabile zi de zi.
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Specificații
ISBN-13: 9783319807874
ISBN-10: 3319807870
Pagini: 736
Ilustrații: XVI, 718 p. 76 illus., 59 illus. in color.
Dimensiuni: 178 x 254 x 37 mm
Greutate: 1.53 kg
Ediția:Softcover reprint of the original 1st ed. 2016
Editura: Springer
Locul publicării:Cham, Switzerland
ISBN-10: 3319807870
Pagini: 736
Ilustrații: XVI, 718 p. 76 illus., 59 illus. in color.
Dimensiuni: 178 x 254 x 37 mm
Greutate: 1.53 kg
Ediția:Softcover reprint of the original 1st ed. 2016
Editura: Springer
Locul publicării:Cham, Switzerland
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De ce să citești această carte
Recomandăm această lucrare oricărui hematolog sau oncolog care caută răspunsuri rapide și fundamentate științific pentru patologii non-maligne. Cititorul câștigă acces la expertiza a peste 60 de specialiști, structurată într-un format interactiv de tip Q&A. Este o resursă indispensabilă pentru gestionarea anemiilor complexe, a tulburărilor de coagulare și a complicațiilor hematologice în sarcină, oferind claritate în deciziile clinice dificile.
Despre autor
Syed A. Abutalib este un expert recunoscut în hematologie și transplant de celule stem, cunoscut pentru capacitatea sa de a sintetiza informații clinice complexe în ghiduri practice. În calitate de editor, a coordonat lucrări fundamentale precum Cell and Gene Therapies, unde a explorat frontierele medicinei regenerative. Alături de Jean M. Connors și Margaret V. Ragni, specialiști de renume în hemostază și tromboză, acesta aduce în Nonmalignant Hematology o viziune multidisciplinară, punând accent pe siguranța pacientului și pe bunele practici în medicina internă și hematologia pediatrică.
Descriere scurtă
This book, in Q&A format, addresses a wide range of clinically relevant topics and issues in Nonmalignant Hematology, or “Benign Hematology,” with a view to offering a robust, engaging tool that will assist every hematologist and oncologist (pediatric and adult equally) in making decisions during day-to-day practice. The entire spectrum of the specialty is covered in more than 60 exceptional chapters written by acknowledged authorities in the field. The content is organized into well-designed broad sections on red cell disorders, platelet and coagulation disorders, coagulopathy in systemic diseases, thromboembolic disease and its management (including surgical), immune system and related disorders, hemostasis and thrombosis during pregnancy and in the newborn and elderly, and Transfusion Medicine. A key aspect of the book is the opportunity it affords expert physicians to express well-reasoned opinions regarding complex issues in Nonmalignant Hematology. Readers willfind that it provides a practical and immediately applicable compendium of answers to often complex and vexing questions. It will appeal to residents, fellows, house officers and more experienced practitioners around the globe.
Cuprins
Part1. Red Blood Cells.- Evaluation of anemia in children and adults.- Iron cycle and pathophysiology of iron homeostasis.- Porphyrias: Diagnosis andmanagement.- Disorders of hemoglobin synthesis: Pathophysiology and diagnosticevaluation.- Management of thalassemias.- Allogeneic hematopoietic celltransplant in ß-thalassemia major.- Sickle cell disease: Prevention ofcomplications.- Sickle cell disease: Management of complications.- Allogeneichematopoietic cell transplant in sickle cell disease.- Anemia of inflammation.-Iron overload: Diagnosis, complications and management.- Megaloblastic andnutritional anemias.- Sideroblastic anemias: Diagnosis and management.- Primaryautoimmune warm antibody hemolytic anemias.- Intrinsic hemolytic anemias: Pathophysiology,diagnosis and management.- Part 2. Platelets and Coagulation System.- Plateletdisorders: Diagnostic tests and their interpretations.- Inherited plateletdisorders: Diagnosis and management.- Acquired platelet disorders: Diagnosisand management.- Immune mediated thrombocytopenia.- Coagulation cascade andfibrinolysis pathway: Assessment in the laboratory.- Abnormalities infibrinolysis pathway and clinical implications.- Congenital disorders offibrinogen: Clinical presentations, diagnosis and management.- Hemophilias Aand B: Diagnosis and management.- Coagulation factor inhibitors: Diagnosis andmanagement.- Rare coagulation factordeficiencies: Diagnosis and management.- von Willebrand disease: Differentialdiagnosis and diagnostic approach to specific subtypes.- von Willebranddisease: Prevention of complications and management of the disease.- Antifibrolytics:Indications and precautions.- Gene therapy for bleeding disorders.- Part 3. Coagulopathyin Systemic Diseases.- Disseminated intravascular coagulopathy.- Coagulopathyin critically ill subjects.- Trauma-associated coagulopathy.- Coagulationrelated issues in malignant hematology: Diagnosis and management.- Unmet clinicalneeds of antithrombotic treatment inBCR/ABL negative myeloproliferative neoplasms.- Bleeding andthrombosis in a cancer patient.- Management of surgical patient with thromboticand bleeding diathesis.- Part 3. Thrombosis and Therapeutics.- Prevention andtreatment of arterial thromboembolism.- mes New Roman","serif"">Prevention of venous thromboembolism.- Diagnostic,prognostic and therapeutic challenges in venous thromboembolisim.- Complicationsof venous thromboembolic disease.- Hereditarythrombophilias: Pathophysiology, timing of testing and familiar testing.- Anti-phospholipidantibodies and syndrome: Complexities in diagnosis and management.- Unidentifiablethrombophilias.- Anticoagulation drugs: Indications, therapeutic monitoring andantidotes.- Heparin induced thrombocytopenia: Diagnosis and management.- Thromboticthrombocytopenic purpura and hemolytic uremic syndrome.- Surgical treatment ofthromboembolic disease.- Part 4. Immune System and Related Disorders.- Nonmalignantleukocyte disorders.- Primary immunodeficiency disorders: Diagnosis andmanagement.- Disorders of phagocytic function:Diagnosis and treatment.- Inherited bone marrow failure syndromes.- Hemophagocytic lymphohistiocytosis: Diagnosisand management challenges.- Lysosomal storage disorders: Hematologyperspective.- Cryoglobulins andcryoglobulinemia.- Part 5. Hemostasis and Thrombosis in Pregnancy, Newbornand Elderly.- Reproductive issues in women with bleeding and thromboticdisorders.- Pregnancy in subjects withhemoglobinopathies: Precautions and management.- Neonatal thrombosis and coagulopathies.-Bleeding and thrombosis in elderly.- Part 6. Transfusion Medicine.- Transfusionsupport: Indications, efficacy and complications.- Human blood antigens andantibodies: Diagnostic and therapeutic implications.- Therapeutic apheresis inhematologic disorders: When and Why?
Notă biografică
SyedAbutalib isAssistant Director of Hematology and Blood and Marrow Hematopoietic CellTransplant Program. Dr. Abutalib earned his medical degree from Dow MedicalCollege in Karachi, Pakistan and subsequently completed a residency in InternalMedicine at Cook County Hospital and a Fellowship in Hematology/Oncology at theUniversity of Illinois at Chicago. During his Fellowship he participated inLeukemia Research at Northwestern Hospital & University of Chicago. Boardcertified in Internal Medicine, Medical Oncology and Hematology, Dr. Abutalibspecializes in benign hematology, malignant hematology and hematopoietic bloodand marrow cell transplant. Dr. Abutalib has been published in severalpeer-reviewed journals, including the American Journal of Hematology, CurrentPharmaceutical Biotechnology, and the American Journal ofClinical Pathology and has written chapters for medicaltextbooks, including Acute Leukemias (2008), Evidence-BasedHematology(2008), Expert Hematology & Oncology Essentials (2014)and Cancer Consult-Expertise for Clinical Practice (2014),Essential Oncology (2015). Dr. Abutalib is the editor of several booksincluding, Cancer Consult-Expertise for Clinical Practice publishedon behalf of Blackwell Wiley Health Sciences. He is on the editorial boardfor Clinical Oncology News and THE ASCO POST magazineand contributes regularly in the column " HowI Manage.." and “Expert Hematology Review”,respectively. Besides his Patients he hold Medical Education dear to hisheart.
Jean M. Connors is an Assistant Professor ofMedicine at Harvard Medical School. Dr Connors received her medical degree fromJohns Hopkins University School of Medicine in Baltimore, Maryland. Shecompleted residency in Internal Medicineat Beth Israel Hospital, Boston,Massachusetts, and fellowships in both Hematology/Oncology and TransfusionMedicine at Brigham and Women’s Hospital, Boston. Dr Connors cares for patientswith inherited and acquired thrombotic and coagulation disorders. AsMedical Director of the Brigham and Women’s Hospital and Dana Farber CancerInstitute Anticoagulation Management Service, Dr Connors overseesanticoagulation practices in outpatient clinical settings. She is also theMedical Director of the Hemostatic Antithrombotic Stewardship program, amulti-disciplinary care delivery program, to ensure judicious and optimal useof anticoagulants and clotting factors across all BWH inpatient services. Shehas participated in a variety of types of clinical trials focusingon anticoagulation including investigator initiated, served on scientificadvisory boards for a number of companies, teaches extensively at many levelsincluding peers in CME courses as well as fellows and residents, and haswritten numerous reviews and chapters in the area of thrombosis-hemostasis.
MargaretRagni is aProfessor of Medicine and Clinical Translational Science at the Universityof Pittsburgh Medical Center, Pittsburgh, Pennsylvania. She received her MDfrom the University of Pittsburgh School of Medicine and a Master of PublicHealth from the University of Pittsburgh School of Public Health. She completedher residency and fellowship in hematology/oncology at the University ofPittsburgh Medical Center in Pittsburgh, where she joined the faculty in 1983.Dr. Ragni’s research interests are in congenital and acquired disorders ofhemostasis and thrombosis, and, in, particular in novel therapeutics forpatients with hemophilia with and without inhibitors. She serves on the Medicaland Scientific Advisory Committee of the National Hemophilia Foundation (NHF),the FDA Blood Products Advisory Committee, the Scientific Committee onHemostasis of the American Society of Hematology,and on the Medical AdvisoryBoard for the Foundation for Women and Girls with Blood Disorders (FWGBD). Shealso served as Co-Chair for the 2014 ASH Annual Meeting; as Co-Chair of theResearch Committee of the Hemostasis & Thrombosis Research Society, and isa member of the Research Committee of the American Thrombosis & HemostasisNetwork. She is past member of the Hemostasis Thrombosis Study Section of theNHLBI, and Co-Chair of the Bleeding Disorders Subcommittee of the NHLBI Stateof the Science Symposium. She serves on Scientific Advisory Boards for Alnylam,Baxalta, Biogen, and Biomarin. She has conducted numerous clinicaltrials, observational studies, retrospective data base analyses,cost-effectiveness analyses, and investigator-initiated new drug trials inhemophilia and von Willebrand disease. She is the medical director of theHemophilia Center of Western PA, providing care for patients with bleeding andclotting disorders, teach and mentor medical students, residents, fellows, andyoung faculty.
Jean M. Connors is an Assistant Professor ofMedicine at Harvard Medical School. Dr Connors received her medical degree fromJohns Hopkins University School of Medicine in Baltimore, Maryland. Shecompleted residency in Internal Medicineat Beth Israel Hospital, Boston,Massachusetts, and fellowships in both Hematology/Oncology and TransfusionMedicine at Brigham and Women’s Hospital, Boston. Dr Connors cares for patientswith inherited and acquired thrombotic and coagulation disorders. AsMedical Director of the Brigham and Women’s Hospital and Dana Farber CancerInstitute Anticoagulation Management Service, Dr Connors overseesanticoagulation practices in outpatient clinical settings. She is also theMedical Director of the Hemostatic Antithrombotic Stewardship program, amulti-disciplinary care delivery program, to ensure judicious and optimal useof anticoagulants and clotting factors across all BWH inpatient services. Shehas participated in a variety of types of clinical trials focusingon anticoagulation including investigator initiated, served on scientificadvisory boards for a number of companies, teaches extensively at many levelsincluding peers in CME courses as well as fellows and residents, and haswritten numerous reviews and chapters in the area of thrombosis-hemostasis.
MargaretRagni is aProfessor of Medicine and Clinical Translational Science at the Universityof Pittsburgh Medical Center, Pittsburgh, Pennsylvania. She received her MDfrom the University of Pittsburgh School of Medicine and a Master of PublicHealth from the University of Pittsburgh School of Public Health. She completedher residency and fellowship in hematology/oncology at the University ofPittsburgh Medical Center in Pittsburgh, where she joined the faculty in 1983.Dr. Ragni’s research interests are in congenital and acquired disorders ofhemostasis and thrombosis, and, in, particular in novel therapeutics forpatients with hemophilia with and without inhibitors. She serves on the Medicaland Scientific Advisory Committee of the National Hemophilia Foundation (NHF),the FDA Blood Products Advisory Committee, the Scientific Committee onHemostasis of the American Society of Hematology,and on the Medical AdvisoryBoard for the Foundation for Women and Girls with Blood Disorders (FWGBD). Shealso served as Co-Chair for the 2014 ASH Annual Meeting; as Co-Chair of theResearch Committee of the Hemostasis & Thrombosis Research Society, and isa member of the Research Committee of the American Thrombosis & HemostasisNetwork. She is past member of the Hemostasis Thrombosis Study Section of theNHLBI, and Co-Chair of the Bleeding Disorders Subcommittee of the NHLBI Stateof the Science Symposium. She serves on Scientific Advisory Boards for Alnylam,Baxalta, Biogen, and Biomarin. She has conducted numerous clinicaltrials, observational studies, retrospective data base analyses,cost-effectiveness analyses, and investigator-initiated new drug trials inhemophilia and von Willebrand disease. She is the medical director of theHemophilia Center of Western PA, providing care for patients with bleeding andclotting disorders, teach and mentor medical students, residents, fellows, andyoung faculty.
Caracteristici
Covers a wide range of topics and issues across the spectrum of non-malignant hematology Offers expert opinions and advice that will assist hematologists and oncologists in daily practice Written in an engaging and helpful Q&A format Features numerous working tables, algorithms, and figures?