Boundary value problems on bounded or unbounded intervals, involving two or more coupled systems of nonlinear differential and integral equations with full nonlinearities, are scarce in the literature. The present work by the authors desires to fill this gap. The systems covered here include differential and integral equations of Hammerstein-type with boundary constraints, on bounded or unbounded intervals. These are presented in several forms and conditions (three points, mixed, with functional dependence, homoclinic and heteroclinic, amongst others). This would be the first time that differential and integral coupled systems are studied systematically. The existence, and in some cases, the localization of the solutions are carried out in Banach space, following several types of arguments and approaches such as Schauder's fixed-point theorem or Guo-Krasnosel'ski¿ fixed-point theorem in cones, allied to Green's function or its estimates, lower and upper solutions, convenient truncatures, the Nagumo condition presented in different forms, the concept of equiconvergence, Carathéodory functions, and sequences. Moreover, the final part in the volume features some techniques on how to relate differential coupled systems to integral ones, which require less regularity. Parallel to the theoretical explanation of this work, there is a range of practical examples and applications involving real phenomena, focusing on physics, mechanics, biology, forestry, and dynamical systems, which researchers and students will find useful.