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Neuroreceptors: Physiology, Pathology, and Therapeutic Targeting

Editat de Deepa S. Mandlik, Mithun Singh Rajput
en Limba Engleză Paperback – feb 2027
Neuroreceptors: Physiology, Pathology, and Therapeutic Targeting offers an in-depth exploration of the cellular and molecular mechanisms underlying brain receptor function and their critical roles in health and disease. This authoritative reference addresses ionotropic, metabotropic, receptor tyrosine kinases, and nuclear receptors, detailing their structures, signaling pathways, and physiological functions. The book emphasizes how receptor malfunctions contribute to neurological and psychiatric conditions such as Parkinson’s disease, Alzheimer’s, schizophrenia, and epilepsy, bridging fundamental biology with clinical relevance. Through comprehensive coverage of experimental methodologies—including imaging, electrophysiology, and molecular pharmacology—it equips researchers and clinicians with practical insights for investigating receptor dynamics and developing targeted therapies. The final sections focus on innovative therapeutic strategies, including gene editing, receptor modulation, and personalized medicine approaches, reflecting current advances in translational neuroscience. This resource is designed to serve as a vital tool for scientists, healthcare professionals, and students seeking a cohesive understanding of receptor biology and its therapeutic potential, fostering progress in neuropharmacology and neurotherapeutics

  • Examines detailed mechanisms of brain receptors and their roles in neurological disorders
  • Integrates molecular, cellular, and clinical perspectives for comprehensive understanding
  • Presents current experimental techniques and translational therapeutic strategies
  • Highlights receptor dysfunction in neurodegenerative and psychiatric diseases
  • Provides a unified resource supporting research, education, and clinical practice
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Specificații

ISBN-13: 9780443511547
ISBN-10: 0443511543
Pagini: 520
Dimensiuni: 152 x 229 mm
Editura: ELSEVIER SCIENCE

Cuprins

Part I – Foundations
1. Introduction to Neuroreceptors: Structure, Function, and Diversity
2. Techniques in Receptor Biology: From Molecular to Systems Neuroscience
3. Neurotransmission and Receptor Dynamics in Health

Part II – Receptor Families in the Nervous System
4. Ionotropic Receptors: Gatekeepers of Fast Synaptic Transmission
5. Metabotropic Receptors: G-Protein Coupling and Intracellular Cascades
6. Receptor Tyrosine Kinases and Neurotrophic Signaling
7. Nuclear Receptors in the Brain: Modulators of Gene Expression and Neuroprotection

Part III – Receptor Dysfunction in Disease
8. Excitotoxicity, Cholinergic Dysfunction, and Neurodegeneration
9. Dopamine and Serotonin Receptors in Psychiatric and Movement Disorders
10. Autoimmunity and Channelopathies: Receptor Targets in Neuromuscular and Central Nervous System Diseases
11. Receptor Mechanisms in Pain, Migraine, and Sensory Disorders

Part IV – Translational Medicine
12. Pharmacological Modulation of Neuroreceptors: Current Therapies and Limitations
13. Emerging Therapies: Gene Editing, Biologics, and Receptor-Targeted Nanomedicine
14. Future Directions: Personalized Medicine and Neuroreceptor-Based Therapeutics