Welcome to the 22nd ACM International Conference on Modelling, Analysis, and Simulation of Wireless and Mobile Systems (MSWiM). This year, MSWiM will be held in the diverse and multi-cultural Miami Beach, USA, a coastal resort city being filled with wonderful landscapes, warm beaches, and eye-catching sites. Over the years, MSWiM has established itself as a leading venue where some of the best research works, trends and directions in the area of modeling and performance evaluation of wireless and mobile systems are presented and discussed. This year is no exception! The 22nd MSWiM will feature a high-quality scientific program, two distinguished keynotes addressed by the following outstanding experts, Prof. Yuanyuan Yang from Stony Brook University, USA, and Prof. Sundaraja Sitharama Iyengar from the Florida International University, USA, and one invited lecture addressed by the distinguished Prof. Stephan Olariu from Old Dominion University, USA. The winner of this year's Reginald G. Fessenden Award will be announced at the ACM MSWiM 2019 banquet dinner. The Reginald G. Fessenden Award has been established five years ago and it is granted to a distinguished researcher to recognize excellence and remarkable contributions in research work in the field of Wireless Communications and Mobile Networking. We take this opportunity to congratulate Prof. Victor C. M. Leung from The University of British Columbia, awarded with the 2018 Reginald G. Fessenden Award in recognition of "his visionary contributions to the convergence of wireless networking and mobile computing technologies". Along with the main conference program, four symposia will be held this year: MobiWac, DIVANet, PE-WASUN and Q2SWinet. Over the years, these symposia have become successful and quite competitive in their own right, covering new research trends, visionary works and several specializations within mobile and wireless systems.