Molecular Life Sciences: An Encyclopedic Reference
Editat de Robert D. Wells, Judith S. Bond, Judith Klinman, Bettie Sue Siler Masters, Ellis Bell, Laurie S. Kagunien Limba Engleză Electronic book text – 28 ian 2018
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Specificații
ISBN-13: 9781461415312
ISBN-10: 1461415314
Dimensiuni: 210 x 279 mm
Ediția:1st ed. 2018
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States
ISBN-10: 1461415314
Dimensiuni: 210 x 279 mm
Ediția:1st ed. 2018
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States
Public țintă
ResearchDescriere
Molecular
Life
Sciences:
An
Encyclopedic
Referenceis
a
partnership
between
the
American
Society
for
Biochemistry
and
Molecular
Biology
and
Springer.
A
major
encyclopedic
work,
it
will
consist
of
multiple volumes
focusing
on
understanding
biological
phenomena
at
the
level
of
molecules
and
their
interactions
that
govern
life
processes. Articles
will
include
those
with
a
focus
on
genes
and
genomes,
and
will
contain
areas
such
as
DNA
Replication,
Repair
and
Recombination,
Genes:
Structure
and
Regulation,
RNA
Structure,
Metabolism
and
Catalysis,
Protein
Synthesis,
Post-translational
Modification
and
Degradation,
Transcription,
Chromatin
and
Epigenetics,
RNA
Mediated
Regulation
and
Non-Coding
RNA,
Genomics,
Proteomics,
Bioinformatics
and
Computational
Approaches
to
Structure
and
Function.
Also
included
will
be
articles
on
Protein
Structure
and
Function
featuring
secondary,
tertiary
and
quaternary
structure,
Protein
Folding,
Protein
Dynamics,
Enzyme
Catalysis
and
Regulation,
Metabolism
and
Bioenergetics,
Ligand
Binding
and
Protein
Interactions,
Mechanisms
of
Signal
Transduction,
Signal
Transduction
and
Immunity,
Molecular
Basis
of
Cell
and
Developmental
Biology,
and
Signal
Transduction
and
Systems
Biology.
The
molecular
aspects
of
cell
structure
and
function
will
be
included
with
articles
on
Glycobiology
and
Extracellular
Matrices,
Lipids
and
Lipoproteins,
Membrane
Transport,
Structure,
Function
and
Biogenesis,
and
Metabolomics
and
Systems
Biology;
also
included
will
be
Unifying
Concepts
and
Theory
from
Biology,
Chemistry
and
Physics
that
are
foundational
for
understanding
the
molecular
life
sciences
together
with
articles
on
Teaching
Perspectives
and
Assessment
Tools.
Each volume will include an overview describing the inter-relatedness of the themes of the section to facets of the molecular life sciences. Detailed overviews will be included along with a number of mini-reviews and shorter discussions of details and definitions, including appropriate experimental approaches.
Each volume will include an overview describing the inter-relatedness of the themes of the section to facets of the molecular life sciences. Detailed overviews will be included along with a number of mini-reviews and shorter discussions of details and definitions, including appropriate experimental approaches.
Cuprins
Allostery
and
Quaternary
Structure.-
Analysis
of
Damaged
DNA.-
Artificial
Chromosomes.-
Artificial
Endonucleases
for
Genome
Editing.-
Bacterial
DNA
Replicases.-
Bacteriophage
and
Viral
Cloning
Vectors.-
Base
Intercalation.-
Bioactivation
of
Carcinogens.-
Bioinorganic
Chemistry.-
Blue/White
Selection.-
Characteristics
of
Enzymes
and
Cloning
Vectors
Used
to
Create
Recombinant
DNA.-
Chemical
Biology
of
DNA
Replication.-
Chemical
Denaturation.-
Chemical
Reaction
Kinetics:
Mathematical
Underpinnings.-
Chromatin
Remodeling
during
Homologous
Recombination
Repair
in
Saccharomyces
Cerevisiae.-
Cis-Regulation
of
Eukaryotic
Transcription.-
Classic
Approaches
to
sequence
determination.-
Classical
and
Alternative
End
Joining.-
Cloning
Vector
Compatibility.-
Computational
methods
in
epigenetic
research.-
Conjugative
Transfer
Systems
and
Classifying
Plasmid
Genomes.-
Conservative
Site-specific
Recombination.-
Control
of
Initiation
in
E.coli.-
Co-Transcriptional
mRNA
Processing
in
Eukaryotes.-
Crosslinking.-
Cycling
of
the
Lagging
Strand
Replicase
During
Okazaki
Fragment
Synthesis.-
Depurination.-
Differential
Equations
and
Chemical
Master
Equation
Models
for
Gene
Regulatory
Networks.-
Direct
Enzymatic
Reversal
of
DNA
Damage.-
Division
of
Labor.-
DNA
Damage
as
a
Therapeutic
Strategy.-
DNA
Damage
by
Endogenous
Chemicals.-
DNA
Methylation
and
Cancer.-
DNA
Polymerase
III
Structure.-
DNA
Repair.-
DNA
Repair
Polymerases.-
DNA
Replication.-
DNA
Topology
and
Topoisomerases.-
DnaA,
DnaB,
DnaC.-
DnaX
Complex
Composition
and
Assembly
Within
Cells.-
Double-strand
Break
Repair.-
Effects
of
adducts
on
Tm.-
Equilibria
and
Bifurcations
in
the
Molecular
Biosciences.-
Eukaryotic
DNA
Replicases.-
Evolution
of
Gene
Regulatory
Networks.-
Evolution
of
Plant
Genomes.-
Exocyclic
Adducts.-
Experimental
Assessment
of
Secondary
Structure
by
Circular
Dichroism.-
Exploring
Nuclear
Lamin–Chromatin
Interactions
and
Their
Signalling
Cascades.-
Expression
Assessment.-
Fatty
Acid
Metabolism.-
Forces
Maintaining
the
Stability
of
Tertiary
Structure.-
Frequency
of
DNA
Damage.-
Gene
Regulation.-
Genes
and
Genomes:
Structure.-
Genomic
Imprinting.-
Genomic
Imprinting
in
Mammals:
Memories
of
Generations
Past.-
Genomic
Sequence
and
Structural
Diversity
in
Plants.-
Genomic
Signature
Analysis
to
Predict
Plasmid
Host
Range.-
Golgi
Apparatus.-
Gyrase
and
Topoisomerase
IV
as
Targets
for
Antibacterial
Drugs.-
HDAC
Inhibitors
Entinostat
and
Suberoylanilide
Hydroxamic
Acid
(SAHA):
The
Ray
of
Hope
for
Cancer
Therapy.-
Helicase
and
Primase
Interactions
with
Replisome
Components
and
Accessory
Factors.-
Helicase
Mechanism
of
Action.-
Hereditary
Breast
and
Ovarian
Cancer
and
Poly(ADP-ribose)
Polymerase
Inhibition.-
Homologous
Recombination
in
Lesion
Bypass.-
Hydrolytic,
Deamination,
and
Rearrangement
Reactions
of
DNA
Adducts.-
Immunology
and
the
Immune
Response.-
In
Silico
Approaches
Towards
Safe
Targetting
of
Class
I
Histone
Deacetylases.-
Inflammation
and
Host
Response
to
Infection.-
Innate
and
Regulatory
B
cells.-
Innate
Immunity.-
Ion
Channels
and
Transporters.-
Kinetics
of
DNA
Damage.-
Large,
Theta-replicating
Plasmids.-
Long-Term
Genetic
Silencing
at
Centromere
and
Telomeres.-
Mammalian
Sugar
Transporters.-
Many
Bacteria
Use
a
Special
Mutagenic
Pol
III
in
Place
of
Pol
V.-
Mass
Spectrometry
Approaches.-
Mathematical
Modelling
of
Plasmid
Dynamics.-
Mathematical
Models
in
the
Sciences.-
Mathematics
of
Fitting
Scientific
Data.-
Mechanism
of
Initiation
Complex
Formation.-
Mechanism
of
PCNA
loading
by
RFC.-
Mechanisms
of
DNA
Recombination.-
Meiotic
Recombination.-
Metamobilomics
–
The
Plasmid
Metagenome
of
Natural
Environments.-
Methods
for
Plant
Genome
Annotation.-
Mismatch
Repair.-
Mitochondrial
Genomes.-
Mitochondrial
Genomes
in
Alveolates.-
Mitochondrial
Genomes
in
Amoebozoa.-
Mitochondrial
Genomes
in
Fungi.-
Mitochondrial
Genomes
in
Invertebrate
Animals.-
Mitochondrial
Genomes
in
Land
Plants.-
Mitochondrial
Genomes
in
Unicellular
Relatives
of
Animals.-
Mitochondrial
Genomes
in
Vertebrate
Animals.-
Mitochondrial
Genomes
of
Chromists
(Stramenopiles,
Haptophytes
and
Cryptophytes).-
Mitochondrial
Genomes
of
Excavata.-
Mitochondrial
Genomes
of
Green,
Red
and
Glaucophyte
Algae.-
Mobile
DNA:
Mechanisms,
Utility,
and
Consequences.-
Modelling
Plasmid
Regulatory
Systems.-
Modes
of
Base
Pairing.-
mRNA
localization
and
localized
translation.-
Naming
and
Annotation
of
plasmids.-
Natural
Products
that
Damage
DNA.-
NMR
Approaches
to
Determine
Protein
Structure.-
NMR
Basis
For
Biomolecular
Structure
(Theory).-
Nucleotide
Excision
Repair.-
Obtaining
Crystals.-
Oxidative
Damage.-
Pattern
Recognition
Receptors:
Evolution,
Redundancy,
and
Cross
Talk.-
PCNA
Structure
and
Interactions
with
Partner
Proteins.-
Peptide
Pheromones
and
their
Protein
Receptors:
Cellular
Signaling
in
Gram-positive
Bacteria.-
Phagocytosis.-
Plant
Genome
Sequencing
Methods.-
Plant
Genomes:
From
Sequence
to
Function
Across
Evolutionary
Time.-
Plant
Transposable
Elements:
Beyond
Insertions
and
Interruptions.-
Plasmid
Cloning
Vectors.-
Plasmid
Genomes,
Introduction
to.-
Plasmid
Incompatibility.-
Plasmids
as
Secondary
Chromosomes.-
Polyglutamine
Folding
Diseases.-
Polymerase
Chain
Reaction.-
Practical
Screening
for
DNA
Damage.-
Predictions
from
Sequence.-
Primary
Structure.-
Prokaryotic
Gene
Regulation
by
Sigma
Factors
and
RNA
Polymerase.-
Prokaryotic
Gene
Regulation
by
Small
RNAs.-
Protein
Domain
Structure
Evolution.-
Rad51
and
Dmc1
Recombinases.-
Reactive
Oxygen
Species.-
Recombination:
Mechanisms,
Pathways,
and
Applications.-
Recombineering.-
Regulation
of
cytoplasmic
mRNA.-
Regulation
of
DSB
Repair
by
Cell-cycle
Signaling
and
the
DNA
Damage
Response.-
Regulation
of
Genetic
Element
Mobility.-
Relevance
of
DNA
Damage
to
Cancer.-
Repeating
Sequences
in
Proteins:
Their
Identification
and
Structural/Functional
Implications.-
Replication
Origin
of
E.
coli
and
the
Mechanism
of
Initiation.-
Replicative
DNA
Helicases
and
Primases.-
Resolution
of
Inflammation.-
Restriction
Endonucleases.-
RNA
Interference.-
RNA
Quality
Control.-
RNA-induced
chromatin
remodeling.-
Role
of
Chromatin
Remodeling
and
DNA
Modification
in
Transcriptional
Regulation.-
Roles
of
Post-translational
Modifications
in
DNA
Double
Strand
Break
Repair.-
Rolling-circle
Replicating
Plasmids.-
Secondary
Structure.-
Selection
with
Antibiotics.-
Selectivity
of
Chemicals
for
DNA
Damage.-
Sequence
Selectivity
of
DNA
Damage.-
Signal
Recognition
in
Lower
Organisms:
Light-Induced
Control
of
Cell
Movement
in
the
Ciliates
Blepharisma
and
Stentor.-
SIKE:
Discovery,
Structure,
and
Function.-
Single
Strand
Annealing.-
Site-specific
Mutagenesis.-
Some
Key
Enzymes
Used
in
Cloning.-
Spectroscopy
of
Damaged
DNA.-
Synthesis
of
Modified
Oligonucleotides.-
Synthetic
Plasmid
Biology.-
TANK-Binding
Kinase
1
(TBK1):
Structure,
Function,
and
Regulation.-
Target-primed
Mobilization
Mechanisms.-
Target-site
Selection.-
Tertiary
Structure
Domains,
Folds
and
Motifs.-
The
Complement
System.-
Theoretical
Aspects
of
Secondary
Structure.-
Toll-Like
Receptor
3:
Structure
and
Function.-
Toll-Like
Receptors:
Evolution
and
Structure.-
Toll-Like
Receptors:
Pathogen
Recognition
and
Signaling.-
Topoisomerases
and
Cancer.-
Transcription
Factor
Classes.-
Transduction
of
Environmental
Signals
by
Prokaryotic
Two
Component
Regulatory
Systems.-
Transposable
elements
and
plasmid
genomes.-
Transposons.-
Types
of
DNA
damage.-
Types
of
Electrophiles.-
Ultraviolet
Light
Damage.-
uORFs:
an
unusual
cis
element
that
regulates
translation.-
Using
Sequence
Information
to
Assess
Evolutionary
Relationships.-
Using
Sequence
Information
to
Identify
Motifs.-
V(D)J
Recombination.-
Why
Do
Proteins
Have
Quaternary
Structure:
Non-allosteric
Proteins.
Notă biografică
Dr.
Ellis
Bell
earned
his
Ph.D.
from
Oxford
University
and
is
currently
a
Professor
of
chemistry
at
University
of
Richmond,
where
his
research
is
focused
on
how
dynamic
aspects
of
protein
structure
are
involved
in
both
catalysis
and
allosteric
regulation
of
multi-subunit
proteins.
He
is
highly
influential
and
well-respected
in
the
field,
particularly
in
the
research
of
protein
structure
and
function,
enzyme
kinetics
and
allosteric
regulation,
protein
folding,
and
structural
genomics.
Dr.
Bell
is
a
governing
member
of
The
Protein
Society
(Education
Committee);
a
member
of
ASBMB,
where
he
initiated
ASBMB’s
Undergraduate
Affiliate
Network;
and
a
member
of
the
National
Science
Foundation’s
Biomolecular
Systems
Cluster,
among
other
organizations.
Caracteristici
Two
volume
series
in
print
format
and
an
online
version
Shows how molecules and their interactions control life processes
Multi-disciplinary approach covers aspects from all relevant areas
Includes supplementary material: sn.pub/extras
Shows how molecules and their interactions control life processes
Multi-disciplinary approach covers aspects from all relevant areas
Includes supplementary material: sn.pub/extras