When ten year old Emily Anders goes missing while in the care of an elderly neighbor, suspicions are raised that threaten the bonds of new friendships. Could one of the neighbors be responsible for her disappearance, or is the tragic history of the once grand old home repeating itself? Missing on Maple Street is told from four points of view - each from a tenant of one of the four apartments in the now worn and tattered Victorian mansion. The story touches on the issues of race, divorce, prejudice, and dementia while keeping the focus on the plight of the young girl who brought joy to the lives of each one of them.