Medicinal Chemistry de Norma K Dunlap

Medicinal Chemistry

Norma K Dunlap

Donna M Huryn

en Limba Engleză Paperback – 17 apr 2018

Medicinal Chemistry teaches essential concepts by focusing on how the field is actually practiced, melding real-world research experience with basic principles and modern methods. Written by practicing medicinal chemists, this textbook is intended for advanced undergraduates and first-year graduate students in biology, chemistry, and biochemistry. Pre-medical or pre-pharmacy students and professionals entering the drug discovery field will also find it a useful reference. Building on a foundation of synthetic organic chemistry and structural biology, the book interweaves therapeutics, case studies, historical context, and techniques for discovering, developing, and optimizing new drugs. Chapters are richly illustrated and include problems and annotated journal references with accompanying exercises and answers.

Authored by practicing medicinal chemists—melding real-world research experience with basic concepts and up-to-date methods
Flexible in presentation— the first five chapters provide a conceptual foundation and historical understanding of the field; subsequent chapters explore the application of concepts. Chapters can be assigned in order of instructor preference and desired emphasis
Presents easy-to-follow tables and descriptions of assays next to their relevance to medicinal chemistry and drug discovery, along with target values—information rarely found all in one place, but is a crucial reference
Case studies and Journal Club use current literature to apply concepts from the text to real-life examples. They are also suitable for flipped classrooms and self-study

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Paperback (2)	944^.12 lei 3-5 săpt.	+40^.42 lei 6-12 zile
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Notă biografică

Norma Dunlap is Professor of Chemistry at Middle Tennessee State University, where she specializes in synthetic organic chemistry and medicinal chemistry. Her research interests include the design and synthesis of bioactive compounds, as well as isolation, identification, and synthesis of bioactive natural products. She holds a PhD in Organic Chemistry from the University of Wyoming and was an NIH Postdoctoral Fellow at the University of Pennsylvania. Prior to an academic career, she was a Senior Research Scientist in drug discovery at Hoffmann-LaRoche.Donna M. Huryn is Research Professor in the Department of Pharmaceutical Sciences at the University of Pittsburgh and Adjunct Professor of Chemistry at the University of Pennsylvania and. Her research focuses on identi_cation, characterization, and optimization of small molecule probes and drugs to treat cancer, neurodegeneration and infectious diseases. She holds a PhD from the University of Pennsylvania and started her career as a medicinal chemist in the pharmaceutical industry. She is the Principal Investigator of the University of Pittsburgh Chemical Diversity Center and is a Fellow of the American Chemical Society.