The three witches, Edna, Heloise, and Agnes have been exonerated and the banishment from their magical home world of Lemain lifted. Heloise enlists the help of Edna and Leonard to search for the scientist that worked with Leonard's father trying to cure lycanthropy. Their quest covers several states in the non-magical world of Pedestria. While searching, they must also avoid hunters who wish to capture or kill them. Meanwhile in Lemain, Rory and Vicky find themselves on opposite sides of a murder investigation. With Rory as the lead investigator and Vicky the main suspect. Can Edna, Heloise, and Leonard elude capture long enough to find the scientist? Can Vicky prove her innocence? Will Agnes's magic recipe box come in handy once again?