Luke, an intelligent, 89-pound yellow Labrador retriever, has an odd ability to understand human conversations and actions. When his owner's girlfriend, Sara Colson, discovers she has breast cancer Luke is the sole secret keeper of her disease. Not knowing if she'll survive, Sara leaves her boyfriend, Ashlundt Jaynes, to shield him from the pain. Luke, knowing how to give unconditional love, is the catalyst bringing the two lovers back together and helps them stay together while Sara and Ashlundt overcome a series of life-changing events. At the heart of Luke's Tale is the story of two lovers and their struggle with unforeseen disillusionment to build a lasting relationship -- and the loving, furry creature who is devoted to them beyond all reason.