By 2018, America has been ravaged by terrorism and biological warfare. One particular bio-weapon, dubbed the Wrath of God, has virtually destroyed the nation- inflicting its victims with wildly varying symptoms and creating horrifying genetic mutations. Those who survive the plague fight for life day to day, struggling to maintain a semblance of society. Rebecca Artemis has been infected by the Wrath in an astonishingly macabre way. Like a vampire, she feeds upon blood to maintain her own deteriorating blood cells. Consumed by guilt over the atrocities she commits, she feverishly seeks to regain her faith and humanity. Making matters worse, Rebecca's condition is exploited by the evil Reverend, who forces her to commit unspeakable acts of violence for his own amusement. For Rebecca, death may be the only true escape from the evil surrounding her, but how many others will perish in rivers of blood on her path to redemption?