The book focuses on the introduction of the basic concepts, processes, and tools used in Lean Six Sigma. A unique feature is the detailed discussion on Design for Six Sigma aided by computer modeling and simulation. The authors present several sample projects in which Lean Six Sigma and Design for Six Sigma were used to solve engineering problems or improve processes based on their own research and development experiences in engineering design and analysis. This book is intended to be a textbook for advanced undergraduate students, graduate students in engineering, and mid-career engineering professionals. It can also be a reference book, or be used to prepare for the Six Sigma Green Belt and Black Belt certifications by organizations such as American Society for Quality.