Betrayal, revenge, and murder take their seats at an anniversary table. Thirteen guests toast their Sicilian-American hosts, Dante and Lisa Santangelo, as a communion-like Chianti and homemade focaccia suddenly turn bitter on their palates. With cries for help frozen on their faces, all thirteen guests are inexplicably silenced forever. Dante and Carlo Santangelo are left orphaned when their parents are murdered by a local Mafioso Don. The two boys grow into men with different values and personalities. Dante is a charmer who wants revenge on his parents' murderers. Carlo is the gentle giant and family protector who wants to recapture the simple life he cherished as a child. When the Japanese attack Pearl Harbor, Carlo immediately enlists in the military while Dante operates the family pizzeria, sending the brothers down different paths-one to serve and one to seek revenge. As Carlo leaves for battle, he makes one request of Dante: to look after his girlfriend. But neither man has any idea of what lies ahead as the war unfolds and life comes full circle to reveal their destinies. Last Supper at Mona Lisa's shares the gripping story of two Sicilian-American men orphaned after their parents are murdered by a Mafioso as one fights for his country and the other plots his revenge.