A new Annihilation event threatens the cosmos, and the consequences will be grave for the Guardians of the Galaxy, S.W.O.R.D. and the royal couple of the united Kree/Skrull Empire, Hulkling and Wiccan! Five different planets have simultaneously come under threat, and this foe may be too big for even the new Guardians to handle. So it's a good thing that Cable is back... locked, loaded and ready to steal the ultimate weapon from the deadliest planet in X-history! Meanwhile, the Black Panther enlists the aid of the Intergalactic Empire of Wakanda - and the legendary M'Baku! But what game is Doctor Doom playing? The war to end all wars is here... and not everyone is going to come home. Collecting: Guardians of the Galaxy (2020) 16-18, Cable Reloaded (2021) 1, The Last Annihilation: Wiccan & Hulking (2021) 1, The Last Annihilation: Wakanda (2021) 1, S.W.O.R.D. (2020) 7