John Doe is an aspiring author. He's 317 years old (passing as 17) and an expert in almost everything. Unfortunately, his memoir, The Last Vampire, has been rejected by nearly every agent in the business. Nobody wants to read about vampires anymore, he's told. The feelings of rejection that might trigger in an ordinary vampire are nothing compared to John's reaction due to his daily struggles with OCD and anxiety. John lives with vampirovirus but finds it difficult to live with the knowledge he's the last of his kind.
When John enrolls in a criminology course, he's partnered up with Angela Ruiz. With no more training than what she's seen on CSI, Angela convinces John they have an obligation to bring down the Six o'Clock Slasher, a serial killer who's confounded the police for two years. As they fumble through their investigation, John begins to suspect the killer might be a vampire. Will John condemn himself to eternal life as the last of his kind, or will he allow a ruthless killer to go free?